Sensitivity analysis showed that no single study significantly influenced the overall association of peripheral blood levels of S100B and epilepsy. Results: a fixed-effects meta-analysis of all 18 studies, including 1,057 unique participants, indicated that patients with epilepsy had significantly increased peripheral blood levels of S100B compared to controls (Hedges g = 1.568, 95% CI =1.431–1.706, P < 0.001). Aberrations in peripheral blood levels of S100B were hypothesized to be related to epilepsy.
Main outcomes and measures: Peripheral blood levels of S100B in patients with epilepsy compared with controls. Studies where data overlapped with other studies were excluded.ĭata extraction and synthesis: investigators extracted, pooled and analyzed data from the included studies using a fixed-effects model in the Comprehensive Meta-Analysis3.3 and R software. Study selection: Original studies and reported data from these search terms are included. The search terms included S100B and calcium-binding protein B in combination with epilepsy. Objective: We performed a meta-analysis to quantitatively summarize the serum S100B data available for patients with epilepsy.ĭata source: Two independent researchers conducted a systematic investigation of the Harvard Hollis+, Open Gray, Clinicaltrials, Wanfangdata, and CNKI databases through Dec 6, 2018, for all studies published in English and Chinese. Importance: Accumulating evidence suggests that serum levels of S100B may play a role in epilepsy. Chan School of Public Health, Boston, MA, United States
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